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Social isolation is such a challenge. It restricts our ability to move around freely and makes us less active. The loss of our routines also creates stress. Unmanaged, stress can lead to the development of high blood pressure, injury to arteries, and brain changes that may contribute to anxiety, depression, and addiction. Worse, chronic stress and social isolation may also contribute to unwanted weight gain by directly triggering the brain’s eating centers, or indirectly decreasing the brain’s ability to induce sleep and exercise.